http://knowyourmeme.com/memes/snakes-on-a-plane

Snakes on crack,” and kick some serious serpent booty. There’s a bunch of unknown actors also onboard to serve mostly as snake food, but a few do survive, including former ER nurse Julianna Margulies, who does a nice turn as the head flight attendant, sparring with the snakes and getting a little cozy with Jackson.

When a young man witnesses a brutal mob murder, FBI agent Neville Flynn to escort his charge safely from Hawaii to Los Angeles to testify the murder. But in an act of self-preservation, the crime boss facing prison smuggles hundreds of poisonous snakes onto the commercial aircraft. The snake in formula, a crate timed to release its deadly cargo halfway over the Pacific. Flynn, along with a frightened flight crew and passengers, must then band together in a desperate attempt to survive.